Results 31 to 40 of about 118,565,731 (151)

Spectrophotometric Assessment of Heme Oxygenase-1 Activity in Leishmania-infected Macrophages

Bio-Protocol, 2020
Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL). Estimation of bilirubin is the basis of HO-1 assay.
Moumita Basu, Shriya Saha, Anindita Ukil
doaj   +1 more source

Role of Heme Oxygenase in Gastrointestinal Epithelial Cells

Antioxidants, 2022
The gastrointestinal tract is a unique organ containing both vascular and luminal routes lined by epithelial cells forming the mucosa, which play an important role in the entry of nutrients and act as a selective barrier, excluding potentially harmful ...
Reiko Akagi
doaj   +1 more source

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

, 2011
Biliverdin reductase-A is a pleiotropic enzyme involved not only in the reduction of biliverdin-IX-alpha into bilirubin-IX-alpha, but also in the regulation of glucose metabolism and cell growth secondary to its serine/threonine/tyrosine kinase activity.
CENINI G, SULTANA R, BUTTERFIELD DA, Sultana, Rukhsana, Cenini, Giovanna, Cesare Mancuso, PERLUIGI, Marzia, D. Allan Butterfield, Preziosi, Paolo, Marzia Perluigi, Barone, Eugenio, DI DOMENICO, FABIO, Butterfield, D. Allan, Paolo Preziosi, PREZIOSI P, Rukhsana Sultana, CINI, Chiara, Mancuso, Cesare, Fabio Di Domenico, Chiara Cini, MANCUSO C, Giovanna Cenini, Eugenio Barone   +22 more
core   +1 more source

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

Biomolecules, 2021
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella   +3 more
doaj   +1 more source

Induction of BVR-A Expression by Korean Red Ginseng in Murine Hippocampal Astrocytes: Role of Bilirubin in Mitochondrial Function via the LKB1–SIRT1–ERRα Axis

Antioxidants, 2022
The beneficial effects of Korean red ginseng extract (KRGE) on the central nervous system (CNS) have been reported. Among the CNS cells, astrocytes possess robust antioxidative properties and regenerative potential.
Sunhong Moon, Chang-Hee Kim, Jinhong Park, Minsu Kim, Hui Su Jeon, Young-Myeong Kim, Yoon Kyung Choi   +6 more
doaj   +1 more source

Purification and Characterization of Human Biliverdin Reductase

Archives of Biochemistry and Biophysics, 1993
Conversion of biliverdin to bilirubin is catalyzed by the cytosolic enzyme biliverdin reductase. We have purified and characterized the human liver reductase and find it to differ extensively from the previously described rat enzyme (H. Fakhrai and M. D. Maines, 1992, J. Biol. Chem.
M D, Maines, G M, Trakshel
openaire   +2 more sources

Bilirubin, Renal Hemodynamics and Blood Pressure

Frontiers in Pharmacology, 2012
Bilirubin is generated from the breakdown of heme by heme oxygenase and the reduction of biliverdin by the enzyme biliverdin reductase. Several large population studies have reported a significant inverse correlation between plasma bilirubin levels and ...
David E. Stec, Peter A. Hosick, Joey P. Granger   +2 more
doaj   +1 more source

Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain.

, 2013
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer's disease, but the ...
PERLUIGI, Marzia, BARONE, EUGENIO, DI DOMENICO, FABIO, Di Domenico F, Barone E, Perluigi M   +5 more
core   +1 more source

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

Neurobiology of Disease, 2019
Hyper-active GSK-3β favors Tau phosphorylation during the progression of Alzheimer's disease (AD). Akt is one of the main kinases inhibiting GSK-3β and its activation occurs in response to neurotoxic stimuli including, i.e., oxidative stress.
Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone   +9 more
doaj   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source