Results 21 to 30 of about 118,565,731 (151)

Biliverdin reductase A is a major determinant of protective NRF2 signaling

Proceedings of the National Academy of Sciences
Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity ...
Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S. Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E. Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M. Snowman, Michael C. Ostrowski, Eugenio Barone, Lakshminarayan M. Iyer, L. Aravind, Sudarshana M. Sharma, Andrew A. Pieper, Bobby Thomas, Solomon H. Snyder, Bindu D. Paul   +21 more
openaire   +4 more sources

Cycling the Wagons for Biliverdin Reductase [PDF]

Journal of Biological Chemistry, 2009
This letter was prompted by our reading of the article by Maghzal et al. (1). Bilirubin (BR) is a major physiologic antioxidant cytoprotectant. Tissue levels are only in nanomolar concentrations, because high levels are neurotoxic, yet BR protects against micromolar levels of oxidants because of a cycle wherein biliverdin (BV) generated by BR ...
Thomas W, Sedlak, Solomon H, Snyder
openaire   +2 more sources

Biliverdin reductase: A major physiologic cytoprotectant [PDF]

Proceedings of the National Academy of Sciences, 2002
Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Bilirubin is a potent antioxidant that we show can protect cells from a 10,000-fold excess of H 2
David E, Baranano, Mahil, Rao, Christopher D, Ferris, Solomon H, Snyder   +3 more
openaire   +2 more sources

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases

Antioxidants, 2020
Bilirubin is a yellow endogenous derivate of the heme catabolism. Since the 1980s, it has been recognized as one of the most potent antioxidants in nature, able to counteract 10,000× higher intracellular concentrations of H2O2.
Sri Jayanti, Libor Vítek, Claudio Tiribelli, Silvia Gazzin   +3 more
doaj   +1 more source

The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases

Frontiers in Cell and Developmental Biology, 2022
Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), free iron and biliverdin, which could then be converted to bilirubin by biliverdin reductase.
Qing Yang, Wenqian Wang
doaj   +1 more source

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares

Pediatric Rheumatology Online Journal, 2020
Background Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin.
Alice S. Chau, Bonnie L. Cole, Jason S. Debley, Kabita Nanda, Aaron B. I. Rosen, Michael J. Bamshad, Deborah A. Nickerson, Troy R. Torgerson, Eric J. Allenspach   +8 more
doaj   +1 more source

Breakdown products of heme catabolism as senescence index in sea lamprey (Petromyzon marinus Linnaeus, 1758)

Frontiers in Marine Science, 2015
Biliverdin and bilirubin are breakdown products of normal heme catabolism, caused by the body's clearance of aged red blood cells which contain hemoglobin.
Sandra Barca, Sergio Silva, María José Servia   +2 more
doaj   +1 more source

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Nature Communications, 2023
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes.
Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager   +8 more
doaj   +1 more source

Biliverdin reductase: more than a namesakeThe reductase, its peptide fragments and biliverdin regulate activity of the three classes of protein kinase C.

Frontiers in Pharmacology, 2012
The expanse of human biliverdin reductase (hBVR) functions in the cells is arguably umatched by any single protein. hBVR is a Ser/Thr/Tyr kinase, a scaffold protein, a transcription factor and an intracellular transporter of gene regulators.
Peter E.M. Gibbs, Cicerone eTudor, Mahin D Maines   +2 more
doaj   +1 more source