Results 51 to 60 of about 118,565,731 (151)

Evidence that biliverdin-IXβ reductase and flavin reductase are identical [PDF]

Biochemical Journal, 1996
A search of the database shows that human biliverdin-IXβ reductase and flavin reductase are identical. We have isolated flavin reductase from bovine erythrocytes and show that the activity co-elutes with biliverdin-IXβ reductase. Preparations of the enzyme that are electrophoretically homogeneous exhibit both flavin reductase and biliverdin-IXβ ...
F, Shalloe, G, Elliott, O, Ennis, T J, Mantle   +3 more
openaire   +2 more sources

Protein/Protein Interactions in the Mammalian Heme Degradation Pathway \u3ci\u3eHEME OXYGENASE-2, CYTOCHROME P450 REDUCTASE, AND BILIVERDIN REDUCTASE\u3c/i\u3e [PDF]

, 2014
Background: Heme oxygenase, cytochrome P450 reductase, and biliverdin reductase are the key enzymes in heme degradation. Results: Specific electrostatic and hydrophobic interactions form the binding interface between heme oxygenase and cytochrome P450 ...
Zuiderweg, Erik R. P., Bagai, Ireena, Becker, Donald F., Ragsdale, Stephen W., Spencer, Andrea L. M.   +4 more
core  

ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity [PDF]

, 2021
Although the role of hydrophilic antioxidants in the development of hepatic insulin resistance and nonalcoholic fatty liver disease has been well studied, the role of lipophilic antioxidants remains poorly characterized.
Gharakhanian, Raffi, Segawa, Mayuko, Young, Margaret R, Adamson, Roslin, Nocito, Laura, Shum, Michael, Abramson, Jeff, Gutierrez, Vincent, Veliova, Michaela, Ngo, Jennifer, Su, Shi, Saxberg, Alexandra D, Stiles, Linsey, Althoff, Thorsten, Faust, Belinda, Mahdaviani, Kiana, Zoghbi, Maria E, Lusis, Aldons J, Liesa, Marc, Martinez, Melissa, Wolf, Dane M, Hevener, Andrea L, Chella Krishnan, Karthickeyan, Carpenter, Elisabeth P, Shintre, Chitra A, Shi Su, Michael Shum, Roslin Adamson, Jeff Abramson, Dane M. Wolf, Vincent Gutierrez, Kiana Mahdaviani, Michaela Veliova, Raffi Gharakhanian, Jennifer Ngo, Chitra A. Shintre, Elisabeth P. Carpenter, Melissa Martinez, Laura Nocito, Mayuko Segawa, Maria E. Zoghbi, Alexandra D. Saxberg, Linsey Stiles, Karthickeyan Chella Krishnan, Belinda Faust, Marc Liesa, Margaret R. Young, Thorsten Althoff, Andrea L. Hevener, Aldons J. Lusis   +49 more
core   +1 more source

Biliverdin reductase-induced phytochrome chromophore deficiency in transgenic tobacco [PDF]

, 2001
Targeted expression of mammalian biliverdin IXalpha reductase (BVR), an enzyme that metabolically inactivates linear tetrapyrrole precursors of the phytochrome chromophore, was used to examine the physiological functions of phytochromes in the ...
Brian Thomas, Keara A. Franklin, Stephen D. Jackson, Lagarias, J. Clark, Marc W. Crepeau, Franklin, Keara A., Montgomery, Beronda L., Terry, Matthew J., Beronda L. Montgomery, Crepeau, Marc W., Jackson, Stephen D., Matthew J. Terry, Thomas, Brian, J. Clark Lagarias   +13 more
core   +2 more sources

A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.
ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger, Nicolas Hebert, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Sandia Adypagavane, Meghan Perkins, Laura Matabishi‐Bibi, France Pirenne, Claire Berquet, Stephane Moutereau, Serge Pissard, Frédéric Galactéros, Michael C. Marden, Pablo Bartolucci   +14 more
wiley   +1 more source

Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase

, 2008
BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion. Mechanistically it
Mulholland, Adrian J, Mantle, Timothy J, Smith, Liam J, Browne, Seamus   +3 more
core   +1 more source

Photophysical and Computational Exploration of Human Serum Albumin Mediated Sensing of Bilirubin via a D‐π‐A Probe

Chemistry–Methods, Volume 6, Issue 7, July 2026.
This work reports the efficacy of an ensemble‐based sensor, A3‐HSA, for selective bilirubin sensing. Experimental and computational studies showed that the strong binding of bilirubin to HSA facilitated the replacement of D‐π‐A probe A3 at the IB site of HSA.
Anamika Bandyopadhyay, Anupam Bhattacharya   +1 more
wiley   +1 more source

Expression of Biliverdin Reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) infection is associated with systemic oxidative stress. Since the heme catabolic pathway plays an important role in antioxidant protection, we attempted to assess the gene expression of key enzymes of heme catabolism, heme ...
Iva Subhanova, Lucie Muchova, Martin Lenicek, Hendrik J Vreman, Ondrej Luksan, Kristyna Kubickova, Miluse Kreidlova, Tomas Zima, Libor Vitek, Petr Urbanek   +9 more
doaj   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Osimertinib Resistance in EGFR‐Mutated Non–Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies

MedComm, Volume 7, Issue 7, July 2026.
This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley   +1 more source