Results 61 to 70 of about 5,817 (208)

Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells [PDF]

Scientific Reports, 2017
AbstractGlioblastoma stem-like cells (GSC) are hypothesized to evade current therapies and cause tumor recurrence, contributing to poor patient survival. Existing cell surface markers for GSC are developed from embryonic or neural stem cell systems; however, currently available GSC markers are suboptimal in sensitivity and specificity.
Michael Zorniak, Paul A. Clark, Benjamin J. Umlauf, Yongku Cho, Eric V. Shusta, John S. Kuo   +5 more
openaire   +2 more sources

Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression

MedComm, Volume 7, Issue 4, April 2026.
A cell‐permeable nanobody strategy was developed to target the intrinsically disordered oncoprotein c‐MYC. A synthetic nanobody, M4, binds the central PEST region of c‐MYC (241–263) and promotes c‐MYC degradation by enhancing Thr58 phosphorylation. Conjugation of M4 to a cell‐penetrating peptide (CPP) generates CPM4, which efficiently accumulates in ...
Yuanyuan Xue, Hao Jiang, Zhaoyun Zong, Xiaolin Tian, Zelong Miao, Ting Li, Yali Wei, Haiteng Deng   +7 more
wiley   +1 more source

Expansion and Refinement of Deep Sequence-Coupled Biopanning Technology for Epitope-Specific Antibody Responses in Human Serum

Viruses, 2020
Identifying the specific epitopes targeted by antibodies elicited in response to infectious diseases is important for developing vaccines and diagnostics.
Nikole L. Warner, Alexandria C. Linville, Susan B. Core, Brechla Moreno, Juan M. Pascale, David S. Peabody, Bryce Chackerian, Kathryn M. Frietze   +7 more
doaj   +1 more source

Propagation Capacity of Phage Display Peptide Libraries Is Affected by the Length and Conformation of Displayed Peptide

Molecules, 2023
The larger size and diversity of phage display peptide libraries enhance the probability of finding clinically valuable ligands. A simple way of increasing the throughput of selection is to mix multiple peptide libraries with different characteristics of
Danna Kamstrup Sell, Anders Wilgaard Sinkjaer, Babak Bakhshinejad, Andreas Kjaer   +3 more
doaj   +1 more source

Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis) [PDF]

, 2011
Background The cotton boll weevil (Anthonomus grandis) is a serious insect-pest in the Americas, particularly in Brazil. The use of chemical or biological insect control is not effective against the cotton boll weevil because of its endophytic life style.
Gustavo R Oliveira, Maria CM Silva, Wagner A Lucena, Erich YT Nakasu, Alexandre AP Firmino, Magda A Beneventi, Djair SL Souza, José E Gomes, José DA de Souza, Daniel J Rigden, Hudson B Ramos, Carlos R Soccol, Maria F Grossi-de-Sa   +12 more
core   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 13, 3 March 2026.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Design and Construction of a Synthetic Nanobody Library: Testing Its Potential with a Single Selection Round Strategy

Molecules, 2023
Nanobodies (Nbs) are single domain antibody fragments derived from heavy-chain antibodies found in members of the Camelidae family. They have become a relevant class of biomolecules for many different applications because of several important advantages ...
María Angélica Contreras, Yunier Serrano-Rivero, Alaín González-Pose, Julieta Salazar-Uribe, Marcela Rubio-Carrasquilla, Matheus Soares-Alves, Natalie C. Parra, Frank Camacho-Casanova, Oliberto Sánchez-Ramos, Ernesto Moreno   +9 more
doaj   +1 more source

Examining the Interactome of Huperzine A by Magnetic Biopanning

PLoS ONE, 2012
Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc.
Wei Guo, Shupeng Liu, Jinliang Peng, Xiaohui Wei, Ye Sun, Yangsheng Qiu, Guangwei Gao, Peng Wang, Yuhong Xu   +8 more
openaire   +4 more sources

An automated microfluidic biosensor with bispecific rabbit monoclonal antibody and nanozyme‐bioenzyme composite for dual antibiotic detection

BMEMat, Volume 4, Issue 1, March 2026.
This study introduces an automated microfluidic biosensor for simultaneous detection of florfenicol and thiamphenicol in environmental water. By integrating a phage‐screened bispecific rabbit monoclonal antibody with a nanozyme‐bioenzyme composite, the system achieves sensitive dual‐antibiotic detection. Coupled with smartphone‐based sensing, it offers
Fuyuan Zhang, Yang Liu, Juntao Wang, Haichao Zhang, Wenlong Yu, Yaxin Sang, Yun Liu, Guangze Yang, Fang Gao, Shuo Wang, Shilun Feng, Xianghong Wang   +11 more
wiley   +1 more source

Using phage display technology to obtain Crybodies active against non-target insects [PDF]

, 2017
The insecticidal Cry toxins produced by Bacillus thuringiensis (Bt) are increasingly important in the biological control of insect pests and vectors of human disease.
Berry, Colin, Dominguez-Flores, Tania, Gantiva-Diaz, Diana Marcela, Luque-Navas, Maria Jose, Osuna, Antonio, Romero-Bosquet, Maria Dolores, Vilchez, Susana   +6 more
core   +2 more sources