Results 1 to 10 of about 4,909 (142)

RNA m5C methylation in cancer: mechanisms and biological impact [PDF]

Oncogenesis
RNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C)
Zhenyu Guan, Wendong Li, Yuting He, Wenzhi Guo   +3 more
doaj   +3 more sources

Recent research advances in RNA m5C methylation modification in liver diseases [PDF]

Frontiers in Molecular Biosciences
RNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C).
Wenjuan Chen, Wenjuan Chen, Lifan Zhang, Lifan Zhang, Xinyu Gu, Yafeng Liu, Yafeng Liu, Shujun Zhang, Shujun Zhang, Xinjun Hu, Xinjun Hu, Penghui Li   +11 more
doaj   +3 more sources

RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis [PDF]

Frontiers in Immunology
The Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong, Yan Xiong, Yanan Li, Weiwei Qian, Weiwei Qian, Qing Zhang   +5 more
doaj   +4 more sources

NSUN2 facilitates tenogenic differentiation of rat tendon-derived stem cells via m5C methylation of KLF2 [PDF]

Regenerative Therapy
Introduction: Tendon-derived stem cells (TDSCs) play a critical role in tendon repair. N5-methylcytosine (m5C) is a key regulator of cellular processes such as differentiation. This study aimed to investigate the impact of m5C on TDSC differentiation and
Wei Lin, Zhi Lin, Lizhi Wu, Youmao Zheng, Huifeng Xi   +4 more
doaj   +4 more sources

RNA m5C methylation: a potential modulator of innate immune pathways in hepatocellular carcinoma [PDF]

Frontiers in Immunology
RNA 5-methylcytosine (m5C) methylation plays a crucial role in hepatocellular carcinoma (HCC). As reported, aberrant m5C methylation is closely associated with the progression, therapeutic efficacy, and prognosis of HCC.
Sun Meng, Bai Jiangtao, Wang Haisong, Li Mei, Zhou Long, Li Shanfeng   +5 more
doaj   +2 more sources

The Role of NSUN Family Genes in m5C Methylation and Diseases [PDF]

Biomedicines
5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes.
Tao Jiang, Nili Jiang, Xuan Chen, Zuming Xiong   +3 more
doaj   +2 more sources

NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic ovary syndrome [PDF]

Scientific Reports
Pyroptosis is a pathogenenic mechanism of polycystic ovary syndrome (PCOS). N5-methylcytosine (m5C) methylation is a RNA modification that affects the progression of diseases. However, its role in PCOS remains not understood.
Guobin Xu, Junlong Wang, Na Gu, Tiansong Yang   +3 more
doaj   +2 more sources

Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain [PDF]

Frontiers in Neurology
IntroductionRNA methylation modifications, including N1 methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytosine (m5C), and 7-methylguanosine (m7G) methylation, have been increasingly implicated in nervous system disorders. The aim of this study
Liangyuan Tan, Liangyuan Tan, Xiaofeng Gan, Dongming Lu, Dongming Lu, Yingye Liang, Yingye Liang, Weiyan Fu, Weiyan Fu, Zhengbao Gan, Zhengbao Gan, Kailong Wang, Kailong Wang, Hongliang Tang, Peipei Yang, Peipei Yang   +15 more
doaj   +2 more sources

The 5-Methylcytosine RNA Modification in Hepatitis B Virus-Negative Hepatocellular Carcinoma: Insights From Long-Read Nanopore Sequencing. [PDF]

Mol Carcinog
ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Sun T, Zhou L, Li X, Xiao R, Sun G, Zhang L, Li Y, Huang W, Li Y, Kuai L, Luo X, Cui H, Chen M.   +12 more
europepmc   +2 more sources

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation [PDF]

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +2 more sources