Results 11 to 20 of about 4,909 (142)

m5C RNA methylation in cancer: from biological mechanism to clinical perspectives

European Journal of Medical Research
Cancer remains a significant global health threat, characterized by high morbidity and mortality rates. Despite advancements, numerous challenges persist in cancer treatment, underscoring the urgent need for novel therapeutic strategies.
Fang Yuan, Yuxuan Xia, Zhen Huang, Huihui Gao, Yuqi Bian, Xiangqin Zhou   +5 more
doaj   +2 more sources

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming. [PDF]

J Cell Mol Med, 2023
AbstractRecently, epigenetics showed essential roles in tumour microenvironment (TME) and immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) modification in TME remains unknown. According to 13 m5C regulators, we evaluated 412 BLCA patients from The Cancer Genome Atlas (TCGA) database.
Yan D, Xie Y, Huang L, Zhang Y, Gu R, Xie H, Huang X, Luo H.   +7 more
europepmc   +3 more sources

The multifaceted role of m5C RNA methylation in digestive system tumorigenesis

Frontiers in Cell and Developmental Biology
5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2.
Xinjun Hu, Yafeng Liu, Shujun Zhang, Kaijie Liu, Xinyu Gu   +4 more
doaj   +3 more sources

m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease

Frontiers in Cell and Developmental Biology
Alzheimer’s disease (AD) is a neurodegenerative disorder caused by a variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors.
Sisi Teng, Cunqiao Han, Jian Zhou, Jian Zhou, Zhenyan He, Weiwei Qian, Weiwei Qian   +6 more
doaj   +3 more sources

Epitranscriptomic profiling of m5C RNA methylation reveals a dynamic response to TSWV infection in tomato [PDF]

Frontiers in Plant Science
Cytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Xinyi Zhao, Yanwei Gong, Yubing Jiao, Wanhong Zhang, Dong An, Yingwen Wang, Binna Lv, Ying Li, Lili Shen, Jinguang Yang   +9 more
doaj   +2 more sources

Role of m5C methylation in digestive system tumors (Review). [PDF]

Mol Med Rep
Currently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang L, Yuan J, Yao S, Wen G, An J, Jin H, Tuo B.   +6 more
europepmc   +3 more sources

Research progress on m5C methylation and its prospects in tumor immunotherapy

口腔疾病防治
Epigenetic modification plays an important role in the biological regulatory process of eukaryotic cells. Tumor immunotherapy is an important means and clinical strategy for the treatment of some cancers.
LU Yunyang, DU Weidong, YU Dongsheng
doaj   +2 more sources

m5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia. [PDF]

Aging (Albany NY), 2023
The development, incidence, and metastasis of tumors are all intimately correlated with 5-methylcytosine (m5C). However, uncertainty surrounds the function of m5C in acute myeloid leukemia (AML). In this study, multicenter AML data were collected and analyzed comprehensively to grasp the gene expression level, clinicopathological characteristics ...
Liu Y, Chen Y, Cai M, Hong Y, Wu X, Li S.   +5 more
europepmc   +3 more sources

Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer. [PDF]

Front Immunol, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and the correlation between m5C methylation and the tumor microenvironment (TME) in prostate cancer remain unknown ...
Yu G, Bao J, Zhan M, Wang J, Li X, Gu X, Song S, Yang Q, Liu Y, Wang Z, Xu B.   +10 more
europepmc   +4 more sources

An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer. [PDF]

Front Cell Dev Biol, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive digestive malignancy due to frequent late-stage diagnosis, rapid progression and resistance to therapy. With increasing PDAC incidence worldwide, there is an urgent need for new prognostic biomarkers and therapy targets.
Yun D, Yang Z, Zhang S, Yang H, Liu D, Grützmann R, Pilarsky C, Britzen-Laurent N.   +7 more
europepmc   +4 more sources