Results 91 to 100 of about 5,548 (154)

Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease

Current Issues in Molecular Biology
RNA methylation plays a critical role in regulating all aspects of RNA function, which are implicated in the pathogenesis of various human diseases.
Yueying Yang, E Wang, Bing Zhou, Yan Lu, Xiaoying Ding, Yao Li   +5 more
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Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Cell Death and Disease
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown.
Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo, Jingwen Yang, Xiulin Wu, Ping Zhou, Fang Huang, Fan Zhu, Wuxiang Guan   +15 more
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5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance

Journal of Translational Medicine
Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li, Tingting Liu, Yajing Dong, Qianqian Gao, Rongzhu Lu, Zhiyong Deng   +5 more
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The role of m5C, m1A and m7G modifications in tumors of urinary system

Frontiers in Cell and Developmental Biology
Malignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Wei Xue, Yuanyuan Zhao, Gong Zhang, Zhiyuan Li, Jixin Li, Xiang Fei   +5 more
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Epitranscriptomic profiling of m5C RNA methylation reveals a dynamic response to TSWV infection in tomato

Frontiers in Plant Science
Cytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Xinyi Zhao, Yanwei Gong, Yubing Jiao, Wanhong Zhang, Dong An, Yingwen Wang, Binna Lv, Ying Li, Lili Shen, Jinguang Yang   +9 more
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m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques

Engineering Reports
5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir   +6 more
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NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus

Journal of Diabetes Investigation
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Jiujiu Liu, Yingjun Chen, Dapeng Wang, Zhaozhao Li   +3 more
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RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Rui-Ke Zhang, Yan Li, Fan-Li Sun, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Wei Wang, Jian-Ge Qiu, Bing-Hua Jiang, Lin Wang   +9 more
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ALYREF promotes the metastasis of nasopharyngeal carcinoma by increasing the stability of NOTCH1 mRNA

Cell Death and Disease
Approximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear.
Yanan Jin, Jijin Yao, Jianchang Fu, Qitao Huang, Yilin Luo, Yafei You, Wangjian Zhang, Qian Zhong, Tianliang Xia, Liangping Xia   +9 more
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m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy

Journal of Experimental & Clinical Cancer Research
Background Lung cancer is the most common malignant tumour and the leading cause of cancer-related death. circular RNAs (circRNAs) have important biological functions and are closely related to tumour development.
Dunyu Cai, Xingcai Chen, Haotian Xu, Qingyun Zhao, Xiaodong Zhou, Jiaxi Wu, Shengyi Yuan, Yihong Gao, Deqing Li, Ruirui Zhang, Wenyi Peng, Gang Li, Aruo Nan   +12 more
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