Results 41 to 50 of about 5,548 (154)

Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning [PDF]

Frontiers in Plant Science, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization and translational fidelity.
Jie Song, Jie Song, Jingjing Zhai, Enze Bian, Yujia Song, Jiantao Yu, Chuang Ma, Chuang Ma   +7 more
openaire   +3 more sources

m5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia

Aging, 2023
The development, incidence, and metastasis of tumors are all intimately correlated with 5-methylcytosine (m5C). However, uncertainty surrounds the function of m5C in acute myeloid leukemia (AML). In this study, multicenter AML data were collected and analyzed comprehensively to grasp the gene expression level, clinicopathological characteristics ...
Liu, Ya, Chen, Yiying, Cai, Maoping, Hong, Yunguang, Wu, Xiang, Li, Songyu   +5 more
openaire   +2 more sources

Novel insights into the role of 5-Methylcytosine RNA methylation in human abdominal aortic aneurysm

Frontiers in Bioscience-Landmark, 2021
Background: It remains largely unclear about the function of 5-methylcytosine (m5C) RNA modification in the context of abdominal aortic aneurysm (AAA).
Yuchen He, Hao Zhang, Fanxing Yin, Panpan Guo, Shiyue Wang, Yihao Wu, Shijie Xin, Yanshuo Han, Jian Zhang   +8 more
doaj   +1 more source

Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Danyang, Li, Yanyan, Liu, Guang, Yang, Mingyu, He, Ligong, Lu   +4 more
openaire   +2 more sources

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2022
5-Methylcytosine (m5C) is an abundant and highly conserved modification in RNAs. The dysregulation of RNA m5C methylation has been reported in cancers, but the regulatory network in ovarian cancer of RNA m5C methylation-related genes and its implication ...
Jie Xu, Xiaoyi Liu, Yanjie Chen, Yuya Wang, Tao Liu, Ping Yi   +5 more
doaj   +1 more source

Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers

Frontiers in Oncology
The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. It plays an important role in various biological processes, including cell metabolism, growth, apoptosis,
Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang   +5 more
doaj   +1 more source

Most m5C Modifications in Mammalian mRNAs are Nonadaptive

Molecular Biology and Evolution
Abstract 5-Methylation (m5C) on mRNA molecules is a prevalent internal posttranscriptional modification in eukaryotes. Although m5C modification has been reported to regulate some biological processes, whether most mRNA m5C modifications are functional is unknown.
Zheng Li, Kai Mi, Chuan Xu
openaire   +2 more sources

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia

Immunity, Inflammation and Disease
Background Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is ...
Qiang Wen, ShouJun Wang, Lili Hong, Siyu Shen, Yibo He, Xianfu Sheng, Xiaofen Zhuang, Shiliang Chen, Ying Wang, Haifeng Zhuang   +9 more
doaj   +1 more source

A novel prognostic risk-scoring system based on m5C methylation regulator-mediated patterns for glioma patients

Molecular Therapy: Oncology
N5-methylcytosine (m5C) methylation modification plays a crucial role in the epigenetic mechanisms underlying tumorigenesis, aggressiveness, and malignancy in diffuse glioma. Our study aimed to develop a novel prognostic risk-scoring system to assess the
Yutong Wen, Xiaotong Chen, Runtong Li, Haiting Xie, Shuai Zhi, Kaitao Wang, Shang Yi, Wen Liang, Haiyan Hu, Shitao Rao, Xiaoya Gao   +10 more
doaj   +1 more source