NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia [PDF]
Clinical EpigeneticsBackground NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies.
Yigang Yuan +13 more
doaj +2 more sources
Targeting the NSUN2–DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer [PDF]
Frontiers in PharmacologyBackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy.
Junyi Zhang +13 more
doaj +2 more sources
Aberrant KIF26B expression promotes bladder cancer progression through driving NSUN2 nuclear localization [PDF]
Journal of Hematology & OncologyAbnormal expression of kinesins has been observed in several types of cancer. The present study provided the first evidence that KIF26B could induce RNA m5C modification in bladder cancer (BCa).
Jia-Ming Wang +6 more
doaj +2 more sources
NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression [PDF]
Cell Death and DiseaseOral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Yunyang Lu +11 more
doaj +2 more sources
NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC [PDF]
HereditasBackground Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored.
Lei Wu +4 more
doaj +2 more sources
NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression [PDF]
Cellular & Molecular Biology LettersBackground Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation.
Wenlong Wang +5 more
doaj +2 more sources
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming [PDF]
Cancer & MetabolismPurpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine ...
Hao Li +7 more
doaj +2 more sources
Oncogenic and immunological roles of NSUN2 in triple negative breast cancer [PDF]
Scientific ReportsImmunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting
Ning An +8 more
doaj +2 more sources
Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA [PDF]
European Journal of Medical ResearchObjective Preeclampsia (PE), a complex multisystem disorder, is a major contributor to maternal and perinatal morbidity and mortality. Enoxaparin, a low-molecular-weight heparin, has shown therapeutic efficacy in preventing various diseases.
Xuan Zhong, Danfeng Zeng
doaj +2 more sources
Lactylation-Boosted m5C RNA Modification Drives Choroidal Neovascularization [PDF]
ResearchAs a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Sipeng Zuo +10 more
doaj +2 more sources