Results 91 to 100 of about 2,316 (143)

FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

npj Precision Oncology
RNA epigenetics is gaining increased attention for its role in the initiation, metastasis, and drug resistance of tumors. These studies have primarily focused on m6A modification. However, despite being the second most abundant modification found in RNA,
Zhenda Wang, Abudurexiti Mierxiati, Wenkai Zhu, Tian Li, Hua Xu, Fangning Wan, Dingwei Ye   +6 more
doaj   +1 more source

NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication

Genomics, Proteomics & Bioinformatics
Abstract RNA modifications have emerged as new efficient targets against viruses. However, little is known about 5-methylcytosine (m5C) modification in the genomes of flaviviruses. Herein, we demonstrate that hepatitis C virus (HCV), dengue virus, and Zika virus exhibit high levels of viral RNA m5C modification. We identified an m5C site
Zhu-Li Li, Yan Xie, Yafen Wang, Jing Wang, Xiang Zhou, Xiao-Lian Zhang   +5 more
openaire   +2 more sources

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications
Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with ...
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
doaj   +1 more source

RNA methyltransferase NSUN2 enhances vasculogenic mimicry and malignant progression of cervical cancer through upregulation of MMP-9. [PDF]

Oncol Lett
Luo J, Li G, Ye M, Xu X, Qi M, Huang J, Shan K, Qu L, Shi H.   +8 more
europepmc   +1 more source

Deep learning model and omics screening highlight angiotensinogen as a 5-methylcytosine (m⁵C) regulated mediator of tumor-microenvironment communication in liver cancer. [PDF]

Front Immunol
Pang H, Wang L, Li Y, Zhou Y.
europepmc   +1 more source

Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases. [PDF]

Epigenetics
Lv F, Jin Y, Yu S, Yang X, Xia S, Ye X, Zhao Q, Hu Y, Zheng A, Wu Y, Tong J.   +10 more
europepmc   +1 more source

Electroacupuncture and Moxibustion Regulate Aerobic Glycolysis and Alleviate Tumor Progression in Mice with Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Zhong R, Wu H, Zhu L, Zhang X, Chen Y, Qi Q, Li G, Wang Z, Huang Y, Deng Z, Shi Y, Li J, Wu L.   +12 more
europepmc   +1 more source

M⁵C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance. [PDF]

Cell Death Dis
Liu J, Zhou L, Yao P, Zhang N, Guo X, Chen F, Yang S, Du X, Wang H, Zhou Y, Chen Y, Zhou L.   +11 more
europepmc   +1 more source

AI-driven virtual screening platform identifies novel NSUN2 inhibitor candidates for targeted cancer therapy: a computational drug discovery approach. [PDF]

NPJ Precis Oncol
Yu S, Peng Q, Wei W, Li X, Long S.
europepmc   +1 more source

NSUN2-Mediated M5c Dysregulation Promotes OSCC Ferroptosis

International Dental Journal
Yunyang Lu, Wei Zhao, Fangyang Shi, Jie Wu, Hui Gao, Hui Zhang, Jiajun Hu, Shiyu Lv, Weidong Du, Runze Li   +9 more
openaire   +1 more source