NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
Cell Death Discovery, 2023 Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang +13 more
doaj +3 more sources
NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer
Cell Death Discovery, 2023 NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function in pancreatic cancer
Guizhen Zhang +9 more
doaj +3 more sources
Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression
Clinical and Translational Medicine, 2022 Background Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa.
Wenkai Zhu +7 more
doaj +3 more sources
NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
Frontiers in Oncology, 2022 Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection.
Xinya Tong +10 more
doaj +3 more sources
NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization
Clinical and Translational MedicineBackground NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses.
Shaomin Zou +11 more
doaj +3 more sources
Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers [PDF]
Frontiers in Oncology, 2022 RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Lingfang Wang +13 more
doaj +3 more sources
NSUN2 Promotes Cardiac Hypertrophy by Activating LARP1–GATA4 Axis
EngineeringPathological cardiac hypertrophy contributes to the development of heart failure (HF). NOL1/NOP2/Sun domain family member 2 (NSUN2) is implicated in pathophysiological processes of many diseases.
Yingqi Liu +25 more
doaj +2 more sources
NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA [PDF]
Scientific ReportsRNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang +6 more
doaj +2 more sources
NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma
Genomics, Proteomics & Bioinformatics, 2023 RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors.
Dan Song +9 more
doaj +3 more sources
NSUN2-mediated RNA m5C modification modulates uveal melanoma cell proliferation and migration
Epigenetics, 2022 RNA 5-methylcytosine (m5C) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles and
Guangying Luo +8 more
doaj +3 more sources