Results 21 to 30 of about 2,316 (143)
Advanced ScienceThe RNA modification, 5‐methylcytosine (m5C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes.
Baoxiang Chen +11 more
doaj +3 more sources
NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus [PDF]
Journal of Diabetes InvestigationIntroduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Jiujiu Liu +3 more
doaj +2 more sources
Journal of Translational MedicineBackground Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang +6 more
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A novel variant in NSUN2 causes intellectual disability in a Chinese family
BMC Medical Genomics, 2023 NSUN2-intellectual disability syndrome, also known as intellectual disability type 5 (MRT5), is an autosomal recessive disorder that is characterized by intellectual disability (ID), postnatal growth retardation, dysmorphic facies, microcephaly, short ...
Qi Yang +4 more
doaj +3 more sources
RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence [PDF]
Oncotarget, 2016 The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and ...
Cai, Xiaoyu +12 more
openaire +5 more sources
PLoS ONE, 2023 BackgroundNOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear.
Lemei Zheng +11 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 The RNA cytosine C5 methyltransferase NSUN2 has a variety of RNA substrates and plays an important role in mRNA metabolism. NSUN2 binds to specific sequences enriched in exosomal mRNAs, suggesting its possible involvement in the sorting of mRNAs into exosomes.
Olga A. Kossinova +6 more
openaire +2 more sources
Aurora-B Regulates RNA Methyltransferase NSUN2 [PDF]
Molecular Biology of the Cell, 2007 Disassembly of the nucleolus during mitosis is driven by phosphorylation of nucleolar proteins. RNA processing stops until completion of nucleolar reformation in G1phase. Here, we describe the RNA methyltransferase NSUN2, a novel substrate of Aurora-B that contains an NOL1/NOP2/sun domain.
Shiho, Sakita-Suto +5 more
openaire +2 more sources
It Takes NSUN2 to Beat the Heat in Rice [PDF]
Developmental Cell, 2020 Cytosine methylation (m5C) exists at low but significant levels in eukaryotic mRNAs, but its biological functions remain elusive. In this issue of Developmental Cell, Tang et al. find that the RNA methyltransferase OsNSUN2 is required for heat tolerance in rice by enhancing translation of specific transcripts under heat stress.
Zhaohai, Zhu, Heng, Zhang
openaire +2 more sources
Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer
Frontiers in Oncology, 2022 BackgroundProstate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various ...
Guangyu Sun +9 more
doaj +1 more source