Results 51 to 60 of about 2,316 (143)

The 5‐Methylcytosine RNA Modification in Hepatitis B Virus‐Negative Hepatocellular Carcinoma: Insights From Long‐Read Nanopore Sequencing

Molecular Carcinogenesis, Volume 65, Issue 4, Page 397-406, April 2026.
ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Tianhan Sun, Liying Zhou, XiaoQing Li, Ryan Xiao, Gaoyuan Sun, Lili Zhang, Yifei Li, Wei Huang, Yayu Li, Lu Kuai, Xuanmei Luo, Hongyuan Cui, Meng Chen   +12 more
wiley   +1 more source

NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner

Clinical and Translational Medicine
NSUN2, a major methyltransferase that catalyzes m5C methylation in eukaryotes, is known to be implicated in the development of multiple cancers. However, its role in colorectal cancer (CRC) and the related molecular mechanisms have yet to be sufficiently
Yuanbo Hu, Chenbin Chen, Kezhi Lin, Xinya Tong, Tingting Huang, Tianle Qiu, Xietao Chen, Jun Xu, Wangkai Xie, Xiangwei Sun, Shiyu Feng, Mingdong Lu, Zhiguang Zhao, Xiaodong Chen, Xiangyang Xue, Xian Shen   +15 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, Volume 13, Issue 9, 13 February 2026.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
doaj   +1 more source

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical Headlights • Glycolytic enzymes regulate lactylation in cancer cells. • Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling. • Targeting lactylation holds promise for cancer therapy. Abstract Cellular lactylation, a recently identified post‐translational modification, has emerged as a ...
Chenyuan Dai, Lihua Wang
wiley   +1 more source

Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lactate accumulation links metabolic reprogramming to epigenetic regulation via protein lactylation. Lactylation drives colorectal cancer proliferation, metastasis, immune escape and chemoresistance. Microbiota‐derived lactate shapes a tumour‐specific lactylation landscape in colorectal cancer.
Ming Liu, Weiwei Li, Yi Ji, Yanqing Chen, Guoli Wei, Jiege Huo, Tao Gui   +6 more
wiley   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

PLoS Genetics, 2011
Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin.
Blanco, Sandra, Kurowski, Agata, Nichols, Jennifer, Watt, Fiona M, Benitah, Salvador Aznar, Frye, Michaela   +5 more
openaire   +5 more sources