Results 61 to 70 of about 2,316 (143)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

NSUN2 mediates distinct pathways to regulate enterovirus 71 replication

Virologica Sinica
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function of m5C deposition is well characterized, other potential roles of NSUN2 in regulating viral replication remain largely unknown.
Liu, Lishi, Chen, Zhen, Zhang, Kui, Hao, Haojie, Ma, Li, Liu, Haizhou, Yu, Baocheng, Ding, Shuang, Zhang, Xueyan, Zhu, Miao, Guo, Xiang, Liu, Yi, Liu, Haibin, Huang, Fang, Peng, Ke, Guan, Wuxiang   +15 more
openaire   +2 more sources

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging

Frontiers in Genetics
NSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou, Jiale Zhou, Yang Han, Fuxi Ji, Renquan Zhang, Yuru Liang, Xudong Zhao, Ruizhe Hou   +7 more
doaj   +1 more source

NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study systematically analyzed the expression levels, clinical features, prognostic value, immune‐related roles, drug sensitivity, and biological functions of NSUN5 in glioma based on the CGGA and TCGA databases. Finally, a machine learning‐based prognostic model was constructed, and the function of NSUN5 was validated through in vitro experiments.
Ye Wenhao, Wu Huan, Zou Xiaoyun, Yang Yuanyuan, Bi Junlei, Liu Changqing, Zhao Mengyi, Zhang Yuyuan, Lu Jin, Wen Hebao, Ma Caiyun   +10 more
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

All‐Trans Retinoic Acid Suppresses Hepatocellular Carcinoma Progression via the CSTB/CYTB Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Cystatin B (CSTB) is highly expressed in hepatocellular carcinoma (HCC) tissues and serum, indicating its potential as an early diagnostic biomarker. Given the known tumour‐suppressive effects of all‐trans retinoic acid (ATRA) in solid tumours, this study investigated whether ATRA inhibits HCC progression by modulating CSTB expression ...
Jing Sun, Jian Zheng, Weiyi Zhu, Yang Bi, Yun He   +4 more
wiley   +1 more source

m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Epigenetic medication, such as RNA 5‐methylcytosine (m5C), is well‐recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated. Methods By utilizing three bulk profiles of NASH patients acquired from GEO and integrative bioinformatic ...
Shuxian Chen, Renquan Duan, Jingyi Qiu, Zhiyu Lei, Wei Chen, Xiumei Li, Zhenyu Gong   +6 more
wiley   +1 more source

Glucose binds and activates NSUN2 to promote translation and epidermal differentiation

Nucleic Acids Research
Abstract Elevations in intracellular glucose concentrations are essential for epithelial cell differentiation by mechanisms that are not fully understood. Glucose has recently been found to directly bind several proteins to alter their functions to enhance differentiation.
Weili Miao, Douglas F Porter, Ya Li, Lindsey M Meservey, Yen-Yu Yang, Chengjie Ma, Ian D Ferguson, Vivian B Tien, Timothy M Jack, Luca Ducoli, Vanessa Lopez-Pajares, Shiying Tao, Paul B Savage, Yinsheng Wang, Paul A Khavari   +14 more
openaire   +2 more sources