Results 71 to 80 of about 2,316 (143)

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
doaj   +1 more source

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

Redox Biology
Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions.
Kaifeng Niu, Zixiang Chen, Mengge Li, Guannan Ma, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, Yongliang Zhao   +8 more
doaj   +1 more source

Machine Learning Integration of Multiomics Data Reveals RNA Modification–Driven Inflammation–Immune Interplay and Predicts Immunotherapy Response in Cervical Cancer

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Objective The interplay between inflammation, immunity, and RNA modification (RM) in the tumor microenvironment (TME) of cervical cancer (CC) remains poorly understood. Materials and Methods We performed integrated analysis of single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics (ST), and bulk RNA‐seq data.
Pengyan Zhang, Xiaoying Li, Jing Cao, Liping Gong, Ling Wang, Litao Sun, Yaoting Wang, Hao Zhang   +7 more
wiley   +1 more source

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing

Advanced Genetics, Volume 6, Issue 4, December 2025.
This review examines recent advances in Oxford Nanopore Technologies direct RNA sequencing, highlighting its expanding capacity to detect RNA modifications beyond m6A. It discusses computational frameworks and basecalling innovations that enable single‐nucleotide and single‐molecule resolution, explores co‐occurring modifications and their regulatory ...
Yaran Liu, Yang Li, Qiang Sun
wiley   +1 more source

Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu, Xiao‐Mei Wu, Yan Hu, Xiao‐Lan Bian, Ya‐Qin Wang, Qiong‐Ni Zhu   +5 more
wiley   +1 more source

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Rui-Ke Zhang, Yan Li, Fan-Li Sun, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Wei Wang, Jian-Ge Qiu, Bing-Hua Jiang, Lin Wang   +9 more
doaj   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function

Nucleic Acids Research
Abstract Enzyme-mediated modifications of tRNA, such as 5-methylcytosine (m5C) installed by nuclear-enriched NOP2/Sun RNA methyltransferase 2 (NSUN2), play a critical role in neuronal development and function. However, our understanding of these modifications' spatial installation and biological functions remains incomplete.
Yulia Gonskikh, Christian Tirrito, Praneeth Bommisetti, Maria Saraí Mendoza-Figueroa, Julian Stoute, Joshua Kim, Qin Wang, Yuanquan Song, Kathy Fange Liu   +8 more
openaire   +2 more sources

NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an m⁵C-YBX1-Dependent Manner

Biomedicines
Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive cancer with high rates of metastasis and poor prognosis. Recent research highlights the role of 5-methylcytosine (m5C) in cancer progression. NSUN2, an m5C
Shuojin Huang, Congyuan Cao, Dongxiao Tang, Yiwen Liu, Wanhang Zhou, Lianlian Liu, Xin Zheng, Qianting He, Anxun Wang   +8 more
doaj   +1 more source

NSUN2-mediated m⁵C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis

Theranostics
Rationale: Anaplastic thyroid carcinoma (ATC) is an extraordinarily aggressive form of thyroid cancer, frequently presenting with locally advanced infiltration or distant metastases at the time of initial diagnosis, thus missing the optimal window for surgical intervention.
Hou, Xiukun, Dong, Qiman, Hao, Jie, Liu, Min, Ning, Junya, Tao, Mei, Wang, Zhongyu, Guo, Fengli, Huang, Dongmei, Shi, Xianle, Gao, Ming, Li, Dapeng, Zheng, Xiangqian   +12 more
openaire   +2 more sources