Results 81 to 90 of about 2,316 (143)

NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis

Molecular Cancer
RNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in acute myeloid
Wenle Ye, Yanchun Zhao, Yutong Zhou, Jiansong Huang, Xiao He, Zhixin Ma, Xin Huang, Chao Hu, Fenglin Li, Qing Ling, Huafeng Wang, Hongyan Tong, Jie Sun, Jie Jin   +13 more
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Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression

Theranostics
Rationale: Internal modifications of mammalian RNA have been suggested to be essential for the maintenance of cardiac homeostasis. However, the role of RNA cytosine methylation (m5C) in the heart remains largely unknown. Methods: Bulk and single cell RNA sequencing data and tissues from the human hearts were exploited for analyzing the expression of ...
Jian, Dongdong, Cheng, Xiaolei, Qi, Datun, Wang, Shixing, Wang, Chenqiu, Shi, Yingchao, Li, Zhen, Jin, Shouyi, Jia, Zhen, Teng, Peng, Pei, Zhen, Gu, Xiaoping, Jian, Liguo, Wang, Wengong, Yi, Xia, Xing, Junyue, Tang, Hao   +16 more
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NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation

Cell Proliferation
ABSTRACTSinusoidal capillarization – key symptoms of liver fibrosis progression – represents potential therapeutic targets. tRNA modification‐mediated tRNA‐derived small RNAs (tsRNAs) play a role in angiogenesis. NSun2, an RNA methyltransferase, generates a significant number of tsRNAs.
Pengcheng Li, Sunyang Ying, Yu Zou, Xin Wang, Runxue Zhang, Cheng Huang, Moyu Dai, Kai Xu, Guihai Feng, Xin Li, Haiping Jiang, Zhikun Li, Ying Zhang, Wei Li, Qi Zhou   +14 more
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The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

Cell Reports
Summary: Acute myeloid leukemia (AML) is one of the most prevalent heterogeneous hematologic malignancies with a complicated etiology. RNA post-transcriptional modifications have been linked to the incidence and progression of AML, while the detailed ...
Songyu Li, Ya Liu, Xiang Wu, Minjia Pan, Hongxia Zhao, Yunguang Hong, Qinghua Zhang, Shushu Hu, Aorong Ouyang, Guangru Li, Minhui Wu, Shanshan Fan, Zhirong Jia, Shanchao Zhao, Guocai Wu, Xiangwei Gao, Zhigang Yang, Zhanghui Chen   +17 more
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Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA

Redox Biology
Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen, Jun Zhang, Ting Zhou, Shan-Shan Rao, Qian Li, Ling-Yan Xiao, Si-Tian Wei, Hong-Feng Zhang   +7 more
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NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer

Cancer Immunology, Immunotherapy
Non-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as a key post-transcriptional regulatory mechanism linked to cancer progression. The persistent expression of PD-L1 in tumor
Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yiran Deng, Lan Li, Bingjie Zeng, Haixia Jiang, Liang Shan, Yiwen Huang, Yunhua Xu, Lifang Ma   +11 more
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NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation

Lipids in Health and Disease
Background Hyperglycemia and dyslipidemia characterize type 2 diabetes mellitus (T2DM). The impact of 5-methylcytosine (m5C) on liver glucose and lipid regulation in T2DM is unclear.
Xianshu Jiang, Xuelan Cheng, Qiu Wan
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Eye manifestations in the NSUN2 intellectual disability syndrome.

International journal of molecular epidemiology and genetics
The NSUN2-intellectual disability syndrome is a rare disorder of the cellular transcriptome that prevents proper t-RNA splicing. This disorder interrupts cellular function and leads to an accumulation of RNA fragments, producing a constellation of symptoms including dysmorphic facies, hypotonia, microcephaly, and short stature.
Graham, Pingree, Amy, Harper, Jordan, Snajczuk, Natario L, Couser   +3 more
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NSUN2 rs13181449 variant decreases the risk of oral cancer development

International Journal of Medical Sciences
NOP2/Sun RNA methyltransferase 2 (NSUN2), encoded by the NSUN2 gene, is a nuclear RNA methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C). Although RNA modification has been widely discussed in cancer development and prognosis, the role of the NSUN2 gene in oral cavity squamous cell carcinoma (OCSCC) is unclear.
Hung, Li-Chung, Huang, Cheng-Chen, Lu, Yen-Ting, Su, Chun-Wen, Lin, Chiao-Wen, Chu, Hsiao-Ju, Yang, Shun-Fa, Lu, Hsueh-Ju   +7 more
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NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
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