Results 31 to 40 of about 79,192 (214)
Control Strategies on Path Tracking for Autonomous Vehicle: State of the Art and Future Challenges
IEEE Access, 2020 Autonomous vehicle technology aims to improve driving safety, driving comfort, and its economy, as well as reduce traffic accident rate. As the basic part of autonomous vehicle motion control module, path tracking aims to follow the reference path ...
Qiangqiang Yao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Tractor Path Tracking Control Method Based on Prescribed Performance and Sliding Mode Control
AgricultureIn addressing the challenges of low path tracking accuracy and poor robustness during tractor autonomous operation, this paper proposes a path tracking control method for tractors that integrates prescribed performance with sliding mode control (SMC).
Liwei Zhu +5 more
doaj +1 more source
Robust Control Strategy of Gradient Magnetic Drive for Microrobots Based on Extended State Observer
Cyborg and Bionic Systems, 2022 Microrobots have great application potential in the biomedical field, to realize the precision and efficiency of microrobots in vivo is research focus in this field. Microrobots are accompanied by various disturbances in complex environment.
Jiawei Lu +5 more
doaj +1 more source
Actuators, 2023 This paper presents a comparative study on the effects of the input configurations of linear quadratic (LQ) controllers on path tracking performance under low friction conditions.
Manbok Park, Seongjin Yim
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Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen +6 more
wiley +1 more source