Results 101 to 110 of about 1,509 (185)

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

aging and disease
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a central hallmark of aging, progressively induces cellular growth arrest and accelerates the production of a pro-inflammatory ...
Qiuqiong, Tang, Deyong, Xiao, Alexander, Veviorskiy, Ying, Xin, Sarah W Y, Lok, Fadi E, Pulous, Peiran, Zhang, Yunfeng, Zhu, Yongming, Ma, Xiao, Hu, Shoulai, Gu, Chenting, Zong, Sabina, Mukba, Mikhail, Korzinkin, Frank W, Pun, Man, Zhang, Alex, Aliper, Lijuan, Wu, Feng, Ren, Li, Zhang, Alex, Zhavoronkov   +20 more
openaire   +2 more sources

Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions. [PDF]

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases.
Adhikari, R, Bhattacharya, K, De Rubis, G, Devkota, SR, Dua, K, Gupta, G, Hansbro, PM, Jha, LA, Jha, SK, Mehndiratta, S, Panth, N, Paudel, KR, Singh, SK, Zhang, Y   +13 more
core   +1 more source

Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Aging Cell, Volume 25, Issue 1, January 2026.
The SC subtype with a pro‐inflammatory, proapoptotic, tissue‐damaging SASP is susceptible to senolytics. The SC subset not killed by senolytics has a pro‐growth/repair SASP. “Senosensitizers” that induce senolytic‐resistant SCs to be converted into SCs that are susceptible to senolytics could enable removal of relatively silent SCs.
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski, Allyson K. Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O. Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P. G. Langhi Prata, Yi Zhu, Renuka Kandhaya‐Pillai, Stefan G. Tullius, Saranya P. Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B. Allison, Tamar Tchkonia, James L. Kirkland   +21 more
wiley   +1 more source

Cellular Senescence, Inflammaging and Cardiovascular Disease

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler   +3 more
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science
Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence‐associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age‐related organ dysfunction and
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
doaj   +1 more source

Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease

Frontiers in Cell and Developmental Biology, 2020
Chronic kidney disease (CKD) presents an ever-growing disease burden for the world’s aging population. It is characterized by numerous changes to the kidney, including a decrease in renal mass, renal fibrosis, and a diminished glomerular filtration rate.
Johannes Schroth, Christoph Thiemermann, Siân M. Henson   +2 more
doaj   +1 more source

Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice [PDF]

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Baker, Jonathan R, Daly, Leah, Hassibi, Shyreen, Ito, Kazuhiro, Kimura, Genki, Kizawa, Yasuo, Nishimoto, Yuki   +6 more
core   +1 more source

Exploring the Intersections of Immunosenescence and Cellular Senescence in Health and Disease [PDF]

This thesis provides a comprehensive investigation into the role of cellular senescence in immune cells, focusing on macrophages and microglia in aging, diseases, and therapeutic responses, as well as the immune landscape during COVID-19.
Melo, Letícya
core   +1 more source

Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect

International Journal of Molecular Sciences
Cellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated secretory phenotype (SASP) (senomorphic).
Agata Henschke, Bartosz Grześkowiak, Olena Ivashchenko, María Celina Sánchez-Cerviño, Emerson Coy, Sergio Moya   +5 more
openaire   +2 more sources

Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy

Aging Cell
ABSTRACT Senescent cells are known to contribute to aging and age‐related diseases. One key way they influence aging is by secreting senescence‐associated secretory phenotype (SASP) factors along with several damage‐associated molecular pattern (DAMP) molecules.
Anna Barkovskaya, Ashley Brauning, Aditi Thambala, Kriti Bhardwaj, Manish Chamoli, Anand Rane, Julie K. Andersen, Amit Sharma   +7 more
openaire   +2 more sources