Cellular senescence: a key therapeutic target in aging and diseases
The Journal of Clinical Investigation, 2022 Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives ...
Lei Zhang +5 more
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TargetsTaken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang +12 more
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Lifestyle interventions to delay senescence
Biomedical JournalSenescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body.
Jan Martel +2 more
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Sarcopenic obesity: prospects of mitochondrial transplantation to combat metabolic deterioration in aging [PDF]
Aging impairs adipose tissue function and contributes to metabolic disorders, such as obesity and insulin resistance. Chronic inflammation is mediated by cytokines, including IL-6, IL-1β, and TNF-α, is a pivotal factor in aging that links mitochondrial ...
Hongxi Xu +4 more
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CHARACTERIZING THE EFFECTS OF ANTIANDROGENS AND SENOLYTICS TO ENHANCE THE THERAPEUTIC RESPONSE TO CASTRATION-RESISTANT PROSTATE CANCER [PDF]
, 2023 Prostate cancer is the most frequently diagnosed cancer in males and the second most common cause of cancer deaths. Androgen deprivation therapy, whether through surgical or chemical castration, is the mainstay for treatment of advanced prostate cancer ...
Silverman, Justin M
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Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventionsa. [PDF]
Chronic obstructive pulmonary disease (COPD) is the world's fourth highest reason for mortality, accounting for 3.5 million deaths in 2021, and about 5% of total global deaths.
Bashyal, S +10 more
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Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]
El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core
The interplay between cell death and senescence in cancer [PDF]
Seminars in Cancer Biology.
Inuzuka, Hiroyuki +2 more
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Senescence associated osteoarthritis: Emerging therapeutics and future directions
Clinical Immunology CommunicationsOsteoarthritis is a degenerative condition that primarily affects the joints. This condition is often marked by the slow degradation of cartilage as well as changes in the subchondral bone. One of the key markers of osteoarthritis is chronic inflammation.
Sheen Razdan, Anush Tomar, Sweta Bawari
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CellsOxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood–brain barrier (BBB) dysfunction.
Jingyuan Ya, Ulvi Bayraktutan
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