Results 121 to 130 of about 1,509 (185)
Aging CellABSTRACTExtracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the inflammatory senescence‐associated secretory ...
Tianpeng Zhang +11 more
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Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential [PDF]
Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to
Johnston, Aaron M +5 more
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Annals of Intensive CareWhereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irrespective of patient’s age.
Paula Martín-Vicente +3 more
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Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
AbstractCellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and
Hongwei Zhang +7 more
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International Journal of Molecular SciencesApigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use. Therefore, the aim of this study was to obtain an amorphous dispersion of AP and evaluate its biological properties.
Anna Stasiłowicz-Krzemień +4 more
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Proceedings of the National Academy of SciencesIncreased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors.
Yidan Liu +13 more
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The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies [PDF]
Background: Disruption of the blood-brain barrier (BBB) contributes to various agerelated neurological disorders. Brain microvascular endothelial cells (BMECs) are the most critical components of the BBB, forming a tightly sealed yet selectively ...
Ya, Jingyuan
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International Journal of Immunopathology and PharmacologyObjectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. Introduction: The process of a cancerous development is facilitated by the accumulation of senescent cells.
Maha M Aziz +4 more
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Do Sleeper Cells Hold the Key to Immortality? Senescent cells in cancer and aging [PDF]
, 2023 Aldridge, Kristin
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International Journal of Biological SciencesBackground: Cellular senescence has emerged as a pivotal focus in cardiovascular research. This study investigates the previously unrecognized role of cellular senescence in septic cardiomyopathy (SCM) and evaluates senomorphic therapy using ruxolitinib (Rux) as a potential treatment option.
Yang, Boshen +9 more
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