Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics [PDF]
Drug Design, Development and TherapyEsther Ugo Alum,1 Sylvester Chibueze Izah,2 Daniel Ejim Uti,1 Okechukwu Paul-Chima Ugwu,1 Peter A Betiang,3 Mariam Basajja,4 Regina Idu Ejemot-Nwadiaro5 1Department of Research Publications, Kampala International University, Kampala, Uganda; 2Department ...
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Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities [PDF]
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Yinhua Zhu +14 more
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Aging and oral squamous cell carcinoma development: the role of cellular senescence [PDF]
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
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Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges [PDF]
CellsCellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki +3 more
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Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes [PDF]
Frontiers in Endocrinology, 2023 Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concept of
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SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
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Senotherapeutics for Brain Aging Management [PDF]
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim B. Singh
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Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
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Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities [PDF]
iScienceSummary: Cellular senescence (CS) shapes lung cancer biology by enforcing durable growth arrest while remodeling the tumor immune microenvironment (TIME) through the senescence-associated secretory phenotype (SASP). In non-small cell lung cancer (NSCLC),
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