Results 41 to 50 of about 1,509 (185)
New Trends in Aging Drug Discovery [PDF]
, 2022 Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that ...
Benhamú Salama, Bellinda +4 more
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Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging
Frontiers in Cell and Developmental Biology, 2020 Aging is defined as a progressive decrease in physiological function accompanied by a steady increase in mortality. The antagonistic pleiotropy theory proposes that aging is largely due to the natural selection of genes and pathways that increase fitness
Harikrishnan Thoppil +3 more
doaj +1 more source
Senescent Cells in Cancer: Wanted or Unwanted Citizens
Cells, 2021 Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer.
Sven E. Niklander +2 more
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Repurposing digoxin for geroprotection in patients with frailty and multimorbidity [PDF]
, 2023 The geroscience hypothesis proposes biological hallmarks of ageing are modifiable. Increasing evidence supports targeting these hallmarks with therapeutics could prevent and ameliorate age-related conditions - collectively termed "geroprotector drugs ...
Bunting, Karina V +4 more
core +1 more source
IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy [PDF]
, 2023 Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion
D'Uva G. +8 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
doaj +1 more source
A Unified Model of Age-Related Cardiovascular Disease [PDF]
, 2022 Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at ...
Bean, Joe +3 more
core +2 more sources
From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease. [PDF]
J NeurochemDuring aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Hayashide LS +5 more
europepmc +2 more sources
Aging Cell, 2023 AbstractAging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence‐associated secretory phenotype (SASP), which significantly contributes to organismal aging and age‐related disorders.
Hanxin Liu +9 more
openaire +2 more sources
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis [PDF]
, 2022 Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation.
Alique Aguilar, Matilde +5 more
core +1 more source