Results 51 to 60 of about 1,509 (185)
Cellular senescence as a possible link between prostate diseases of the ageing male [PDF]
, 2021 Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome — known as the senescence-associated secretory phenotype — is responsible for a systemic ...
Akbar, AN +7 more
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Cellular senescence in asthma: from pathogenesis to therapeutic challenges
EBioMedicine, 2023 Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan +5 more
doaj +1 more source
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
doaj +1 more source
A systematic scoping review of vascular cell senescence in atherosclerosis: An innovative perspective and therapeutic approach [PDF]
, 2023 A senescência celular é um processo complexo caracterizado pela incapacidade das células de se dividirem, o que acaba por comprometer a função celular. Quando este processo ocorre em células vasculares, os eventos protrombóticos, pró-inflamatórios, e pró-
José Alexander dos Santos de Canha
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Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending. Despite its severe socioeconomic impact, KOA remains, to date, an incurable disease.
Andrea Bernetti +6 more
openaire +3 more sources
Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
doaj +1 more source
Effects of senescence on the tumour microenvironment and response to therapy [PDF]
, 2023 Cellular senescence is a state of durable cell arrest that has been identified both in vitro and in vivo. It is associated with profound changes in gene expression and a specific secretory profile that includes pro-inflammatory cytokines, growth factors ...
Haston, S +5 more
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Frontiers in Neurology, 2023 Drosophila melanogaster is a valuable model organism for a wide range of biological exploration. The well-known advantages of D. melanogaster include its relatively simple biology, the ease with which it is genetically modified, the relatively low financial and time costs associated with their short gestation and life cycles, and the large number of ...
Sean J. Miller +4 more
openaire +3 more sources
Senescence, aging and disease throughout the gastrointestinal system [PDF]
Senescence is an irreversible cell cycle arrest -characterized by morphological alterations, genomic instability and secretome changes- that profoundly affects the tissue structure and function.Accumulating evidence indicates that senescence plays a ...
Ferreira-Gonzalez, Sofía +3 more
core +1 more source
, 2022 The development of therapeutic strategies aimed at the aging process of cells has attracted increasing attention in recent decades due to the involvement of this process in the development of many chronic and age-related diseases.
Alshadidi, Raghad
core +2 more sources