Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
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The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
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Idiopathic pulmonary fibrosis - novel approach on future treatment [PDF]
Journal of Education, Health and Sport, 2023 Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal pulmonary disease that leads to progressive fibrosis and extremely poor resaults.. Since the etiology is unknown, there are highly limited options of the IPF treatment.
Katarzyna Pacek +7 more
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Senotherapeutics for Brain Aging Management [PDF]
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim B. Singh
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Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
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Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer [PDF]
Current OncologySince cancer is often linked to the aging process, the importance of cellular senescence in cancer has come under the spotlight. While senescence in cancer cells can serve as a natural barrier against cancer due to its proliferation arrest, its secretory
Satoru Meguro +15 more
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Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review [PDF]
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Andrea Bernetti +6 more
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Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications [PDF]
Diabetes & Metabolism Journal, 2023 Cellular senescence is accelerated by hyperglycemia through multiple pathways. Therefore, senescence is an important cellular mechanism to consider in the pathophysiology of type 2 diabetes mellitus (T2DM) and an additional therapeutic target. The use of
Kanako Iwasaki +2 more
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Aging and oral squamous cell carcinoma development: the role of cellular senescence [PDF]
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
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Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [PDF]
Current Research in Pharmacology and Drug Discovery, 2021 It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is
Carmela Rita Balistreri +2 more
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