Results 91 to 100 of about 1,581 (183)

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

Senescence and senotherapeutics: a new field in cancer therapy

Pharmacology & Therapeutics, 2019
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer.
Myrianthopoulos, Vassilios, Evangelou, Konstantinos, Vasileiou, Panagiotis V.S., Cooks, Tomer, Vassilakopoulos, Theodoros P., Pangalis, Gerassimos A., Kouloukoussa, Myrsini, Kittas, Christos, Georgakilas, Alexandros G., Gorgoulis, Vassilis G.   +9 more
openaire   +4 more sources

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source

Defining Microbiota‐Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age‐Related T Cell Senescence

Aging Cell, Volume 24, Issue 12, December 2025.
An age‐associated accumulation of senescent T cells is characterized by increased cellular damage and the secretion of pro‐inflammatory molecules collectively known as the senescence‐associated secretory phenotype (SASP). In the present study, we demonstrate that this accumulation of senescent T cells in aged hosts is accompanied by a reduction in ...
Nia Paddison Rees, Jessica Conway, Ben Dugan, Sayeda S. Amir, Aimee Parker, Simon R. Carding, Niharika A. Duggal   +6 more
wiley   +1 more source

Ignoring the planet: A critical blind spot for research on ageing

Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.
Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels, Ognian Neytchev, Gillian Borland, Polina Germushkina, Richard Johnson, Peter Stenvinkel, Tina Woods   +6 more
wiley   +1 more source

SGLT2 inhibitors as a novel senotherapeutic approach

npj Aging
Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescence-associated secretory phenotype (SASP).
Zeynep Elif Yesilyurt-Dirican, Ce Qi, Yi-Chian Wang, Annika Simm, Laura Deelen, Alia Hafiz Abbas Gasim, Fiona Lewis-McDougall, Georgina M. Ellison-Hughes   +7 more
openaire   +2 more sources

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

eLife, 2020
Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expression pathway analysis was used to compare the functional networks of genes affected by RG-7112, a pure ...
Hosni Cherif, Daniel G Bisson, Matthew Mannarino, Oded Rabau, Jean A Ouellet, Lisbet Haglund   +5 more
openaire   +3 more sources

Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota [PDF]

Biological ageing is a time-dependent process that has implications for health and disease. Cellular senescence is a key driver in ageing and age-related diseases.
Basit, Abdul W, Favaron, Alessia, Gaisford, Simon, Mai, Yang, McCoubrey, Laura E, Sangfuang, Nannapat, Taub, Marissa, Xie, Yuan   +7 more
core  

Senotherapeutics for healthy ageing [PDF]

Nature Reviews Drug Discovery, 2018
Laura J, Niedernhofer, Paul D, Robbins
openaire   +2 more sources

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [PDF]

The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Boukos, Nikos, Evangelou, Konstantinos, Georgiou, Maria, Gorgoulis, Vassilis G., Havaki, Sophia, Kambas, Konstantinos, Kotopoulos, Nicholas, Kotsinas, Athanassios, Lagopati, Nefeli, Lougiakis, Nikolaos, Magkouta, Sophia, Marakos, Panagiotis, Palaiologou, Anastasia, Papaspyropoulos, Angelos, Petty, Russell, Pippa, Natassa, Pispas, Stergios, Pouli, Nicole, Sampaziotis, Fotios, Tamvakopoulos, Constantin, Thanos, Dimitris, Thanos, Dimitris Foivos, Veroutis, Dimitris   +22 more
core   +2 more sources