Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
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Aging and Senotherapeutics [PDF]
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2019 One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence.
Ivana Čepelak, Slavica Dodig
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Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy [PDF]
Current Issues in Molecular BiologyCellular senescence is an irreversible cell cycle arrest, triggered by stressors like telomere shortening, DNA damage, and oncogenic signaling. These cells, often referred to as ‘zombie cells’ because they cease dividing yet resist apoptosis, drive the ...
Steven Januar Kusmanto
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Senotherapeutics: Different approaches of discovery and development [PDF]
Molecules and CellsJee Hyeon Yoon, Ho Jae Han
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Cellular Senescence in Health, Disease, and Lens Aging [PDF]
PharmaceuticalsBackground: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease.
Ying Qin, Haoxin Liu, Hongli Wu
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Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy [PDF]
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
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Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics [PDF]
PharmaceuticalsBackground/Objectives: Cellular senescence is characterised by irreversible cell cycle arrest and the secretion of a proinflammatory phenotype. In recent years, senescent cell accumulation and senescence-associated secretory phenotype (SASP) secretion ...
Jose Alberto Santiago-de-la-Cruz +3 more
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Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies. [PDF]
J Transl Int MedAging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu TE, Zhou Z.
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Cellular senescence, neuroinflammation, and microRNAs: Possible interactions driving aging and neurodegeneration in the hippocampal neurogenic niche. [PDF]
Aging BrainCellular senescence influences normal physiology and ageing-related diseases, including neurodegeneration. Senescent cells accumulate with age in the brain, secreting pro-inflammatory factors that promote neuroinflammation, which has been linked to ...
Polzer O, Kinloch E, Fitzsimons CP.
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The potential for senotherapy as a novel approach to extend life quality in veterinary medicine [PDF]
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
Zoë J. Williams +4 more
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