Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis [PDF]
Stem Cell Research & TherapyBackground Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis.
Valeria Mazzone +7 more
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The promise of organ rejuvenation to overcome the shortage in organ transplantation [PDF]
Nature CommunicationsOrgan shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered.
Mukhammad Kayumov +6 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets [PDF]
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
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Upregulation of senescence-associated gene expression levels in human gingival tissue affected by periodontitis. [PDF]
J PeriodontolBackground: Accumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age-associated diseases.
Kim SJ +7 more
europepmc +3 more sources
Cellular senescence in cancer: molecular mechanisms and therapeutic targets [PDF]
MedCommAging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin +5 more
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Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
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Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Carla Luís +13 more
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Cells, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Masayoshi Suda +7 more
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IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy
Frontiers in Cell and Developmental Biology, 2023 Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion
Donatella Romaniello +14 more
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Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
Frontiers in Cellular and Infection Microbiology, 2023 In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other.
Zhiqiang Li +10 more
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