Results 51 to 60 of about 1,581 (183)
Mitochondrial Homeostasis and Cellular Senescence [PDF]
, 2019 Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and ...
Chronopoulos, Efstathios +9 more
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From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
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Implications of cellular senescence in paediatric pituitary tumours [PDF]
, 2023 The long-standing view of senescent cells as passive and dysfunctional biological remnants has recently shifted into a new paradigm where they are main players in the development of many diseases, including cancer.
Gonzalez-Meljem, Jose Mario +1 more
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Senotherapeutic Drugs: A New Avenue for Skincare?
Plastic & Reconstructive Surgery, 2021 Summary: Skin aging is an outward manifestation of other cellular and molecular aging processes occurring elsewhere in the body. These processes are known collectively as the “hallmarks” of aging, which are a series of basic health maintenance mechanisms that fail over time. Cellular senescence is one of the most studied of the
Lee, BP, Harries, LW
openaire +4 more sources
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Cells, 2020 The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may ...
Marco Malavolta +4 more
doaj +1 more source
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities
Cancer Biology & MedicineSenescent macrophages have emerged as dynamic cells within the tumor microenvironment that significantly promote tumor progression through complex cellular and molecular functional alterations.
Tianzi Wang +4 more
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Exploring the Intersections of Immunosenescence and Cellular Senescence in Health and Disease [PDF]
This thesis provides a comprehensive investigation into the role of cellular senescence in immune cells, focusing on macrophages and microglia in aging, diseases, and therapeutic responses, as well as the immune landscape during COVID-19.
Melo, Letícya
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Senolytics and exercise: Dual modalities for rejuvenating muscle
The Journal of Physiology, EarlyView.Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican +4 more
wiley +1 more source