Results 71 to 80 of about 1,581 (183)
Fisetin is a senotherapeutic that extends health and lifespan [PDF]
EBioMedicine, 2018 Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches.
Yousefzadeh, Matthew J. +21 more
openaire +2 more sources
The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits
Aging Cell, Volume 25, Issue 2, February 2026.Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen +18 more
wiley +1 more source
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss
Aging Cell, Volume 25, Issue 2, February 2026.Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli +3 more
wiley +1 more source
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models. [PDF]
, 2022 peer reviewedIncreasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related ...
Akyildiz, Erdogan Oguzhan +4 more
core +1 more source
Therapy-induced senescence in breast cancer: an overview
Exploration of Targeted Anti-tumor TherapyOutcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of their ...
Suraj Narayanan Chembukavu +1 more
doaj +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Adwaita R. Parab +8 more
wiley +1 more source
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, Volume 38, Issue 1, 2 January 2026.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Health-Extending Medicine in an Aging Society: Perspectives of Medical Research and Practice [PDF]
Ageing is the primary risk factor for cancer, dementia, and cardiovascular diseases. As the understanding of the biology of ageing constantly improves, there are already initial approaches to geroprotection, which seek to reduce the age-related risk of ...
Antebi, Adam +12 more
core +1 more source
New perspectives on the physiological basis of muscle loss
Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley +1 more source