Results 81 to 90 of about 1,581 (183)

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

JCI Insight
Cachexia is a debilitating skeletal muscle wasting condition for which we currently lack effective treatments. In the context of cancer, certain chemotherapeutics cause DNA damage and cellular senescence. Senescent cells exhibit chronic activation of the transcription factor NF-κB, a known mediator of the proinflammatory senescence-associated secretory
Davis A. Englund, Alyssa M. Jolliffe, Gabriel J. Hanson, Zaira Aversa, Xu Zhang, Xinyi Jiang, Thomas A. White, Lei Zhang, David G. Monroe, Paul D. Robbins, Laura J. Niedernhofer, Theodore M. Kamenecka, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
openaire   +2 more sources

The senotherapeutic potential of phytochemicals for age-related intestinal disease [PDF]

During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or “inflammaging”) appear to be connected to gut ...
Costa, Célia Maria, Kirkland, James L, Madureira, Raquel, Pedrosa, Sílvia Santos, Reis, Flávio   +4 more
core   +1 more source

Cellular Senescence: Defining a Path Forward. [PDF]

, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as
Adams, Peter D, Alimonti, Andrea, Bennett, Dorothy C, Bischof, Oliver, Bishop, Cleo, Campisi, Judith, Collado, Manuel, Demaria, Marco, Evangelou, Konstantinos, Ferbeyre, Gerardo, Gil, Jesús, Gorgoulis, Vassilis, Hara, Eiji, Jurk, Diana, Krizhanovsky, Valery, Maier, Andrea B, Narita, Masashi, Niedernhofer, Laura, Passos, João F, Robbins, Paul D, Schmitt, Clemens A, Sedivy, John, Serrano, Manuel, von Zglinicki, Thomas, Vougas, Konstantinos, Zhou, Daohong   +25 more
core   +10 more sources

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao, Zicheng Zhang, Tong Li, Yuyin Jiang, Yuanxin Liu, Tingting Lv, Lianju Qin, Yunxia Zhu, Wei Tang   +8 more
wiley   +1 more source

On the past, present and future of senotherapeutics. [PDF]

NPJ Aging
Quarta M, Demaria M.
europepmc   +4 more sources

From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
During aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Lívia de Sá Hayashide, Bruna Pessoa, Gustavo Dias, Bruno Pontes, Rafael Serafim Pinto, Luan Pereira Diniz   +5 more
wiley   +1 more source

Cell Senescence in Heterotopic Ossification

Biomolecules
The formation of bone outside the normal skeleton, or heterotopic ossification (HO), occurs through genetic and acquired mechanisms. Fibrodysplasia ossificans progressiva (FOP), the most devastating genetic condition of HO, is due to mutations in the ...
Robert J. Pignolo, Frederick S. Kaplan, Haitao Wang   +2 more
doaj   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Senescence, aging and disease throughout the gastrointestinal system [PDF]

Senescence is an irreversible cell cycle arrest -characterized by morphological alterations, genomic instability and secretome changes- that profoundly affects the tissue structure and function.Accumulating evidence indicates that senescence plays a ...
Ferreira-Gonzalez, Sofía, Forbes, Stuart J, Hara, Eiji, Matsumoto, Tomotoro   +3 more
core   +1 more source